Zinc 30mg - This is far more zinc than needed for it's benefits, and even then it's only beneficial as a dietary supplement for men when it comes to weight loss. And that's because it plays an important role in the production of testosterone production. A zinc deficiency for men can lead to significant weight gain due to this issue as a metabolic slowdown is part and parcel of low t. It does have some impact on women, but it's substantially less important to a healthy metabolism.
Selenium (as Selenomethionine) 70mcg - There is some evidence for selenium's use in gundry md metabolic advanced although the evidence is shaky. The problem with the selenium studies is that they are corralation studies rather than clinical trials. People with less selenium in their diet do have higher BMI, but that in and of itself is also generally true of people who simply have healthier diets and is true of most vitamins and minerals. It is true that low selenium levels can cause metabolic syndrome, however, it is a very rare deficiency.
Chromium (as Chromium Picolinate) 100mcg - This is perhaps the best mineral inclusion in gundry md metabolic advanced, there are several trials which suggest that chromium supplementation can lead to minor difference in weight loss whilst dieting vs a control group. Whilst it was only a difference of about 5% more every 6 weeks in morbidly obese women it is still a statistically noticeable difference. And deficiency in chromium can cause metabolic syndrome, although like selenium this is not a common issue. Restricting calories would ultimately be far more effective than chromium dietary supplements.
Cinnamon Bark 250mg - So cinnamon can be useful in losing weight, just in much, much greater volumes than 250mg. In fact you need 2g per pound of body weight of cinnamon extract for it to be effective. It resulted in the trial participants losing 2.59% more body weight than those without. The Gundry md metabolic advanced dietary supplement does not contain nearly enough to be of any use at all.
Berberine HCl (Berberis aristata bark and root extract) 250mg - Berberine does have an effect on blood glucose levels, which has a loose connection with weight loss. In terms of Berberine having an impact on the development of fat cells, which we suspect is the reason for its inclusion in Gundry md metabolic advanced, this has only been shown in rodent models. And unfortunately most rodent studies do not translate to working for humans. Then there is also the fact that like cinnamon bark a human sized dose would be in grams, not milligrams even if it does prove to be effective.
Turmeric Root Extract (95% Curcuminoids) 100mg - Curcuminoids do have an effect on metabolic syndrome specifically, although this was in a higher dose 1500mg. As for any other benefits from the turmeric root extract it needs to be dosed at above 500mg, an argument could be made that it's anti inflammatory effects could help people train harder thus lose weight faster or support joints for overweight people engaging in exercise. But, still this is not a reason to buy metabolic advanced as the dose is far too low for it's health benefits.
BioPerine 10mg - Bioperine is a fine inclusion in pretty much any supplement, it does little to combat weight gain or overall health, but it does help the body absorb other vitamins and minerals so this is a fine inclusion in gundry md metabolic advanced.