Since Hi-Tech Pharmaceuticals Lipodrene fat burner supplement uses a proprietary blend we have no way of knowing how much of anything is included in the mix.
We only know what the company has chosen to tell us, which is that Lipodrene contains 100mg of caffeine and 25mg of Ephedra extract.
Ephedra 25mg - Certain types of Ephedra have been banned in the United States since 2004, but Hi-Tech Pharmaceuticals Thermo-Z™ proprietary ephedra extract blend is legal. Presumably, this is because it doesn’t contain the dangerous ephedrine alkaloids that have been banned nationwide. Studies done in the 80s and 90s on ephedrine, the active compound in ephedra, do point towards it being effective for weight loss and fat burning. However, it is unclear whether these benefits are available in ephedra that has been altered to remove the ephedrine alkaloids.
Caffeine 100mg - A common ingredient in fat-burning supplements, caffeine is a stimulant and an effective ingredient for stimulating thermogenesis. Alongside increasing metabolism, caffeine provides energy that can help you keep training or living an active lifestyle even while running a calorie deficit.
Here are the rest of the ingredients in Lipodrene. Since Lipodrene uses a proprietary blend, we have no idea whether these ingredients are included at effective or for that matter safe doses.
Senegalia Berlandieri Extract - There is very little information about this plant available. The top source on Google is a press release from Hi-Tech Pharma claiming Senegalia Berlandieri extract is 20% more effective than Ephedra. But with no independent studies available there is no way to verify this or even ascertain what Senegalia Berlandieri extract actually does.
Phenylethylamine - This is a stimulant that, as we mentioned, poses several health risks.
Methylsynephrine - Again, this is a stimulant. However, there is no serious scientific work supporting its effectiveness in the area of weight loss.
Synephrine HCI - As mentioned, this too is a stimulant that poses health risks.
Theobromine - Sort of like a slow-release form of caffeine, theobromine is thought to enhance the effect of other ingredients and possibly induce thermogenesis. We could find one recent scientific study that supports these claims (3).
Methylhexanamine HCI - Also known as 1,3-dimethylamylamine, DMAA, and dimethylamylamine, this compound is not considered safe. It has been banned by numerous sports bodies around the world and the FDA has repeatedly warned against its use in supplements, even going so far as to issue letters to individual manufacturers using the substance in their products. Regardless of whether or not this is effective for weight loss, the potential safety concerns far outweigh any benefits. Yet another reason to avoid this fat burner.
Cassia Nomame Extract - Another ingredient that little is known about.
Dihydroxybergamottin - This compound is found naturally in grapefruit, we have no idea if it helps with weight loss, there is no evidence available.
5-Methoxytryptamine HCI - Used in the treatment of tuberculosis, this is an anti-inflammatory. We’re not entirely sure why it has been included, but perhaps it helps offset the effects of the dangerous amount of stimulants this fat burner includes.
Yohimbine HCI - This is a diuretic that will indeed help you lose weight, however, the loss will only be temporary and due to dehydration…far from the best way to lose weight.
Green Tea Extract - This is actually a decent ingredient and the only ingredient in Lipodrene besides caffeine that is included on our best fat burners for men list of top ingredients. The main benefit of Green Tea extract is that it binds fat in the stomach causing it to pass out of the body rather than be stored.
Resources
1. https://www.nejm.org/doi/full/10.1056/nejmc1502505
2. https://www.nejm.org/doi/full/10.1056/NEJM200012213432502
3. https://pubmed.ncbi.nlm.nih.gov/31965293/