Does Capsaicin Cream Work?

Capsaicin is the active compound found in chili peppers that gives them their characteristic heat. It has long been used in traditional medicine for its analgesic properties. When applied topically, capsaicin interacts with nerve cells in the skin, blocking pain signals from reaching the brain. This reduces the perception of pain and provides much-needed relief for muscle and joint discomfort.

The Science Behind Capsaicin's Pain-Relieving Action

Capsaicin works by depleting a neurotransmitter called Substance P, which is involved in transmitting pain signals to the brain. By reducing Substance P levels, capsaicin effectively dulls the sensation of pain. Additionally, capsaicin's warming or cooling effect on the skin can also contribute to pain relief by distracting nerve receptors and providing a soothing sensation.

Studies on Capsaicin for Pain Relief

Several randomized controlled trials have investigated the efficacy of capsaicin cream for chronic pain. A meta analysis conducted by Mason et al. evaluated the results of six double-blind placebo-controlled trials involving 656 patients with neuropathic conditions. The analysis revealed a relative benefit of on a 10 point pain scale of 1.4 for capsaicin cream more than a placebo, with a number needed to deemed a complete and effective standalone treatment of 5.7. For musculoskeletal conditions, three double-blind placebo-controlled trials involving 368 patients showed a relative benefit of 1.5 and a number needed to treat of 8.1.

These findings suggest that although the efficacy of topically applied capsaicin cream for chronic pain may be moderate to mild, but it can make a good combination treatment.

It is worth noting that achieving double-blind conditions in placebo-controlled trials using capsaicin cream can be challenging due to the characteristic burning sensation it produces, meaning that patients would often know if they were in the placebo group.

High Dose Capsaicin Cream Studies

In a recent study conducted by a specialized pain clinic, researchers evaluated the potential analgesic action of an 8% capsaicin cream in patients with myofascial pain syndrome. The study involved 40 participants who were randomly assigned to receive either the capsaicin cream or a placebo cream.

Before the creams were applied, a local anesthetic was used to numb the area of interest. The cream was then applied to the trigger point, represented by the area with pain upon palpation. The participants were monitored for skin tolerability parameters, and their pain levels were assessed before and at various time points after the cream application.

The results of this study showed that the capsaicin cream was well tolerated and led to a significant decrease in pain scores over the 60-day evaluation period. None of the participants in the placebo group experienced hyperemia or burning sensations, while 85% of the participants in the capsaicin group reported these sensations, which subsided within 24 hours.

What Are The Uses of Capsaicin Cream

Capsaicin cream has shown promise in relieving pain associated with several conditions, including:

Capsaicin Cream for Arthritis

Arthritis is a common condition characterized by joint inflammation and pain. Capsaicin cream has been found to effectively reduce pain in different types of arthritis, including osteoarthritis and rheumatoid arthritis. Regular application of capsaicin cream can help alleviate joint discomfort and improve mobility.

Diabetic Neuropathy

Diabetic neuropathy is a nerve damage condition that affects individuals with diabetes. It often manifests as tingling, numbness, or burning sensations in the hands and feet. Capsaicin cream has been studied as a potential treatment for diabetic neuropathy, providing relief from the associated pain and discomfort.

Migraines and Headaches

Migraines and severe headaches can be debilitating, affecting daily activities and quality of life. Capsaicin cream, when applied to the temples or forehead, may help alleviate migraine symptoms and reduce the intensity and duration of headaches.

Muscle Pain and Sprains

Capsaicin cream has been widely researched for its effectiveness in relieving muscle pain caused by strains and sprains. It can provide localized relief, promoting muscle relaxation and reducing discomfort.

Postherpetic Neuralgia

Postherpetic neuralgia is a complication of shingles, a viral infection that affects nerves and causes intense pain. Capsaicin cream may help alleviate the persistent pain associated with postherpetic neuralgia, providing much-needed relief and improving quality of life.

Other Potential Uses

Research suggests that capsaicin may have a role in managing other conditions, such as psoriasis, obesity, gastrointestinal disorders, and even certain types of cancer. While more research is needed to fully understand its benefits in these areas, capsaicin's pain-relieving properties offer potential for broader applications.

Using Capsaicin Cream: Guidelines for Safe and Effective Application

When using capsaicin cream, it's essential to follow proper application guidelines to ensure safety and maximize its effectiveness. Here are some important considerations:

1. Start with the Right Strength

Capsaicin creams are available in different strengths. It is recommended to begin with a lower concentration, such as 0.025% or Zacin®, and gradually increase if necessary. This allows your body to acclimate to the cream and minimizes the risk of skin irritation.

2. Apply a Thin Layer

Apply a pea-sized amount of capsaicin cream to the affected area and gently rub it in until fully absorbed. Avoid applying the cream to broken or damaged skin, as this may cause irritation.

3. Wash Hands Thoroughly

After applying capsaicin cream, wash your hands with soap and water to prevent accidental contact with sensitive areas such as the eyes or mouth. If treating your hands, wait for at least 30 minutes before washing to ensure proper absorption.

4. Avoid Heat and Hot Water

To prevent exacerbating the warming or cooling effect of capsaicin, avoid exposing the treated area to direct heat sources, such as heating pads, hot showers, or baths. Additionally, refrain from using hot tubs, saunas, or other heat-inducing activities immediately after applying capsaicin cream.

5. Consistency is Key

Capsaicin cream may take time to provide noticeable relief. It is recommended to use the cream regularly for 4-6 weeks before assessing its effectiveness. If you experience positive results, continue using the cream as long as pain persists. Regular check-ins with your healthcare provider can help evaluate its ongoing benefits.

6. Potential Side Effects

While capsaicin cream is generally safe, some individuals may experience mild side effects, including temporary burning, itching, redness, or dryness at the application site. These effects are usually short-lived and diminish with continued use. However, if the burning sensation becomes unbearable or if a rash develops, discontinue use and consult your healthcare provider.

7. Precautions and Allergies

Before using capsaicin cream, it's important to inform your healthcare provider about any allergies, skin conditions, or other medications you are taking. Discuss any potential interactions or contraindications to ensure the safe use of capsaicin cream.